Key to prevention of heart attacks is identification of patients at risk – so they can receive preventative care. To this end, a cardiac (exercise) stress test is commonly performed to monitor obstructed blood flow. Yet, this standard stress test difficult for many to perform and it is only accurate when blood flow is impaired by more than about 70%. Although a nuclear stress test is more accurate, it also only monitors blood flow. To attain better diagnostics, researchers have strived for decades to directly monitor oxygen in the heart – and not simply blood flow. Cardio-Theranostics research has now achieved this goal and can now monitor oxygen in a needle-free, contrast-free, and treadmill-free cardiac stress test (patent pending). The analysis reveals coronary artery disease as well as other physiological factors missed by limitations of current stress tests. Our publication in Science Translational Medicine has been widely acclaimed with 73 reviews in other journals (Hsin-Jung Yang, et. al. Science Translational Medicine 29 May 2019: Vol. 11, Issue 494).